Bendamustine Related Impurity 13 - Names and Identifiers
Bendamustine Related Impurity 13 - Physico-chemical Properties
Molecular Formula | C12H15N3O5
|
Molar Mass | 281.26 |
Density | 1.420±0.06 g/cm3(Predicted) |
Melting Point | 170.5-171.5 °C(Solv: ethanol (64-17-5)) |
Boling Point | 582.1±50.0 °C(Predicted) |
Flash Point | 305.8°C |
Solubility | Methanol |
Vapor Presure | 2.17E-14mmHg at 25°C |
Appearance | Solid |
Color | White Crystalline |
pKa | 4.62±0.10(Predicted) |
Storage Condition | Keep in dark place,Inert atmosphere,Room temperature |
Refractive Index | 1.649 |
Bendamustine Related Impurity 13 - Introduction
5-[2-(methylamino)-5-nyro-ilino]-5-oxo-pentanoic acid is a compound whose chemical formula is C12H15N3O6.
Nature:
-Appearance: 5-[2-(methylamino)-5-nitro-anilino]-5-oxo-pentanoic acid is a pale yellow to orange-yellow solid.
-Solubility: It is insoluble in water, but can be dissolved in organic solvents, such as methanol, ethanol and dichloromethane.
-Stability: It is relatively stable at room temperature, but may decompose in the presence of high temperature, strong acid, strong alkali or oxidant.
Use:
- 5-[2-(methylamino)-5-nitro-ilino]-5-oxo-pentanoic acid is often used as a dye intermediate for the synthesis of organic dyes and pigments.
-It is also used as a chemical reagent and pharmaceutical intermediate.
Method:
The preparation method of 5-[2-(methylamino)-5-nitro-anilino]-5-oxo-pentanoic acid includes the following steps:
1. First, 2-amino -5-nitrobenzaldehyde and methylamine are reacted under acidic conditions to generate 2-methylamino-5-nitrobenzaldehyde.
2. Then, 2-methylamino-5-nitrobenzaldehyde reacts with diethyl glutarate under alkaline conditions to generate 5-[2-(methylamino)-5-nitro-anilino]-5-oxo-pentanoic acid.
Safety Information:
- 5-[2-(methylamino)-5-nitro-anilino]-5-oxo-pentanoic acid will not have obvious toxic effects on the human body under normal use conditions. However, any chemical should be handled properly, avoiding direct contact with skin, eyes or inhalation of its dust, etc.
-During use and storage, follow appropriate laboratory safety practices, such as wearing appropriate protective equipment (e. g. gloves, goggles, face shields, etc.).
-In the event of accidental exposure to the compound or discomfort, seek medical attention and provide details of the chemical.
Last Update:2024-04-09 21:01:54